Publications


Holland, N. D., Holland, L. Z., & Somorjai, I. M. L. (2022). Three‐dimensional fine structure of fibroblasts and other mesodermally derived tissues in the dermis of adults of the Bahamas lancelet (Chordata, Cephalohordata), as seen by serial block‐face scanning electron microscopy. Journal of Morphology, jmor.21502. https://doi.org/10.1002/jmor.21502
Fujimura, Y., & Holland, L. Z. (2022). COVID-19 microthrombosis: unusually large VWF multimers are a platform for activation of the alternative complement pathway under cytokine storm. International Journal of Hematology, 115(4), 457–469. https://doi.org/10.1007/s12185-022-03324-w
Holland, L. Z., & Holland, N. D. (2021). Cephalochordates: A window into vertebrate origins. In S. F. Gilbert (Ed.), Evolutionary Developmental Biology (Vol. 141, pp. 119–147). Elsevier Academic Press Inc.
Holland, L. Z., & Ocampo Daza, D. (2018). A new look at an old question: when did the second whole genome duplication occur in vertebrate evolution? Genome Biology, 19. https://doi.org/10.1186/s13059-018-1592-0
Ono, H., Koop, D., & Holland, L. Z. (2018). Nodal and Hedgehog synergize in gill slit formation during development of the cephalochordate Branchiostoma floridae. Development, 145(15). https://doi.org/10.1242/dev.162586
Holland, N. D., & Holland, L. Z. (2017). The ups and downs of amphioxus biology: a history. International Journal of Developmental Biology, 61(10–12), 575–583. https://doi.org/10.1387/ijdb.160395LH
Yue, J. X., Kozmikova, I., Ono, H., Nossa, C. W., Kozmik, Z., Putnam, N. H., Yu, J. K., & Holland, L. Z. (2016). Conserved noncoding elements in the most distant genera of cephalochordates: The Goldilocks principle. Genome Biology and Evolution, 8(8), 2387–2405. https://doi.org/10.1093/gbe/evw158
Yue, J. X., Holland, N. D., Holland, L. Z., & Deheyn, D. D. (2016). The evolution of genes encoding for green fluorescent proteins: insights from cephalochordates (amphioxus). Scientific Reports, 6. https://doi.org/10.1038/srep28350
Holland, L. Z. (2015). The origin and evolution of chordate nervous systems. Philosophical Transactions of the Royal Society B-Biological Sciences, 370(1684). https://doi.org/10.1098/rstb.2015.0048
Holland, L. Z. (2015). Genomics, evolution and development of amphioxus and tunicates: The Goldilocks principle. Journal of Experimental Zoology Part B-Molecular and Developmental Evolution, 324(4), 342–352. https://doi.org/10.1002/jez.b.22569
Holland, N. D., Holland, L. Z., & Holland, P. W. H. (2015). Scenarios for the making of vertebrates. Nature, 520(7548), 450–455. https://doi.org/10.1038/nature14433
Holland, N. D., Holland, L. Z., & Heimberg, A. (2015). Hybrids between the Florida amphioxus (Branchiostoma floridae) and the Bahamas lancelet (Asymmetron lucayanum): Developmental morphology and chromosome counts. Biological Bulletin, 228(1), 13–24.
Holland, L. Z. (2015). Evolution of basal deuterostome nervous systems. Journal of Experimental Biology, 218(4), 637–645. https://doi.org/10.1242/jeb.109108
Yue, J. X., Yu, J. K., Putnam, N. H., & Holland, L. Z. (2014). The transcriptome of an Amphioxus, Asymmetron lucayanum, from the Bahamas: A window into chordate evolution. Genome Biology and Evolution, 6(10), 2681–2696. https://doi.org/10.1093/gbe/evu212
Koop, D., Chen, J., Theodosiou, M., Carvalho, J. E., Alvarez, S., de Lera, A. R., Holland, L. Z., & Schubert, M. (2014). Roles of retinoic acid and Tbx1/10 in pharyngeal segmentation: amphioxus and the ancestral chordate condition. Evodevo, 5. https://doi.org/10.1186/2041-9139-5-36
Striedter, G. F., Belgard, T. G., Chen, C. C., Davis, F. P., Finlay, B. L., Gunturkun, O., Hale, M. E., Harris, J. A., Hecht, E. E., Hof, P. R., Hofmann, H. A., Holland, L. Z., Iwaniuk, A. N., Jarvis, E. D., Karten, H. J., Katz, P. S., Kristan, W. B., Macagno, E. R., Mitra, P. P., … Wilczynski, W. (2014). NSF workshop report: Discovering general principles of nervous system organization by comparing brain maps across species. Journal of Comparative Neurology, 522(7), 1445–1453. https://doi.org/10.1002/cne.23568
Holland, L. Z., Carvalho, J. E., Escriva, H., Laudet, V., Schubert, M., Shimeld, S. M., & Yu, J. K. (2013). Evolution of bilaterian central nervous systems: a single origin? Evodevo, 4. https://doi.org/10.1186/2041-9139-4-27
Holland, L. Z. (2013). Evolution of new characters after whole genome duplications: Insights from amphioxus. Seminars in Cell & Developmental Biology, 24(2), 101–109. https://doi.org/10.1016/j.semcdb.2012.12.007
Short, S., Kozmik, Z., & Holland, L. Z. (2012). The Function and Developmental Expression of Alternatively Spliced Isoforms of Amphioxus and Xenopus laevis Pax2/5/8 Genes: Revealing Divergence at the Invertebrate to Vertebrate Transition. Journal of Experimental Zoology Part B-Molecular and Developmental Evolution, 318B(7), 555–571.
Onai, T., Takai, A., Setiamarga, D. H. E., & Holland, L. Z. (2012). Essential role of Dkk3 for head formation by inhibiting Wnt/beta-catenin and Nodal/Vg1 signaling pathways in the basal chordate amphioxus. Evolution & Development, 14(4), 338–350. https://doi.org/10.1111/j.1525-142X.2012.00552.x
Holland, L. Z. (2012). Amphioxus genomics. Briefings in Functional Genomics, 11(2), 87–88. https://doi.org/10.1093/bfgp/els014
Holland, L. Z., & Onai, T. (2012). Early development of cephalochordates (amphioxus). Wiley Interdisciplinary Reviews: Developmental Biology, 1(2), 167–183. https://doi.org/10.1002/wdev.11
Koop, D., Holland, L. Z., Setiamarga, D., Schubert, M., & Holland, N. D. (2011). Tail regression induced by elevated retinoic acid signaling in amphioxus larvae occurs by tissue remodeling, not cell death. Evolution & Development, 13(5), 427–435. https://doi.org/10.1111/j.1525-142X.2011.00501.x
Wu, H. R., Chen, Y. T., Su, Y. H., Luo, Y. J., Holland, L. Z., & Yu, J. K. (2011). Asymmetric localization of germline markers Vasa and Nanos during early development in the amphioxus Branchiostoma floridae. Developmental Biology, 353(1), 147–159. https://doi.org/10.1016/j.ydbio.2011.02.014
Holland, N. D., & Holland, L. Z. (2010). Laboratory spawning and development of the Bahama lancelet, Asymmetron lucayanum (Cephalochordata): fertilization through feeding larvae. Biological Bulletin, 219(2), 132–141.
Onai, T., Yu, J. K., Blitz, I. L., Cho, K. W. Y., & Holland, L. Z. (2010). Opposing Nodal/Vg1 and BMP signals mediate axial patterning in embryos of the basal chordate amphioxus. Developmental Biology, 344(1), 377–389. https://doi.org/10.1016/j.ydbio.2010.05.016
Holland, L. Z., & Sower, S. A. (2010). “Insights of Early Chordate Genomics: Endocrinology and Development in Amphioxus, Tunicates and Lampreys”: Introduction to the symposium. Integrative and Comparative Biology, 50(1), 17–21. https://doi.org/10.1093/icb/icq039
Holland, L. Z., & Short, S. (2010). Alternative Splicing in Development and Function of Chordate Endocrine Systems: A Focus on Pax Genes. Integrative and Comparative Biology, 50(1), 22–34. https://doi.org/10.1093/icb/icq048
Holland, L. Z. (2010). BIO - Linda Z. Holland. Evolution & Development, 12(2), 109–112. https://doi.org/10.1111/j.1525-142X.2010.00397.x
Koop, D., Holland, N. D., Semon, M., Alvarez, S., de Lera, A. R., Laudet, V., Holland, L. Z., & Schubert, M. (2010). Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: Insights into early anterior-posterior patterning of the chordate body plan. Developmental Biology, 338(1), 98–106. https://doi.org/10.1016/j.ydbio.2009.11.016
Boldrin, F., Martinucci, G., Holland, L. Z., Miller, R. L., & Burighel, P. (2009). Internal fertilization in the salp Thalia democratica. Canadian Journal of Zoology-Revue Canadienne De Zoologie, 87(10), 928–940. https://doi.org/10.1139/z09-083
Holland, L. Z. (2009). Chordate roots of the vertebrate nervous system: expanding the molecular toolkit. Nature Reviews Neuroscience, 10(10), 736–746. https://doi.org/10.1038/nrn2703
Onai, T., Lin, H. C., Schubert, M., Koop, D., Osborne, P. W., Alvarez, S., Alvarez, R., Holland, N. D., & Holland, L. Z. (2009). Retinoic acid and Wnt/beta-catenin have complementary roles in anterior/posterior patterning embryos of the basal chordate amphioxus. Developmental Biology, 332(2), 223–233. https://doi.org/10.1016/j.ydbio.2009.05.571
Kaltenbach, S. L., Holland, L. Z., Holland, N. D., & Koop, D. (2009). Developmental expression of the three iroquois genes of amphioxus (BfIrxA, BfIrxB, and BfIrxC) with special attention to the gastrula organizer and anteroposterior boundaries in the central nervous system. Gene Expression Patterns, 9(5), 329–334. https://doi.org/10.1016/j.gep.2009.02.003
Holland, N. D., Campbell, T. G., Garey, J. R., Holland, L. Z., & Wilson, N. G. (2009). The Florida amphioxus (Cephalochordata) hosts larvae of the tapeworm Acanthobothrium brevissime: natural history, anatomy and taxonomic identification of the parasite. Acta Zoologica, 90(1), 75–86. https://doi.org/10.1111/j.1463-6395.2008.00343.x
Beaster-Jones, L., Kaltenbach, S., Koop, D., Yuan, S. C., Chastain, R., & Holland, L. Z. (2008). Expression of somite segmentation genes in amphioxus: a clock without a wavefront? Development Genes and Evolution, 218(11–12), 599–611. https://doi.org/10.1007/s00427-008-0257-5
Yu, J. K., Wang, M. C., Shin, T., Kohara, Y., Holland, L. Z., Satoh, N., & Satou, Y. (2008). A cDNA resource for the cephalochordate amphioxus Branchiostoma floridae. Development Genes and Evolution, 218(11–12), 723–727. https://doi.org/10.1007/s00427-008-0228-x
Holland, L. Z., Holland, N. D., & Gilland, E. (2008). Amphioxus and the evolution of head segmentation. Integrative and Comparative Biology, 48(5), 630–646. https://doi.org/10.1093/icb/icn060
Holland, L. Z., Albalat, R., Azumi, K., Benito-Gutierrez, E., Blow, M. J., Bronner-Fraser, M., Brunet, F., Butts, T., Candiani, S., Dishaw, L. J., Ferrier, D. E. K., Garcia-Fernandez, J., Gibson-Brown, J. J., Gissi, C., Godzik, A., Hallbook, F., Hirose, D., Hosomichi, K., Ikuta, T., … Holland, P. W. H. (2008). The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Research, 18(7), 1100–1111. https://doi.org/10.1101/gr.073676.107
Short, S., & Holland, L. Z. (2008). The evolution of alternative splicing in the Pax family: The view from the basal chordate amphioxus. Journal of Molecular Evolution, 66(6), 605–620. https://doi.org/10.1007/s00239-008-9113-5
Putnam, N. H., Butts, T., Ferrier, D. E. K., Furlong, R. F., Hellsten, U., Kawashima, T., Robinson-Rechavi, M., Shoguchi, E., Terry, A., Yu, J. K., Benito-Gutierrez, E., Dubchak, I., Garcia-Fernandez, J., Gibson-Brown, J. J., Grigoriev, I. V., Horton, A. C., de Jong, P. J., Jurka, J., Kapitonov, V. V., … Rokhsar, D. S. (2008). The amphioxus genome and the evolution of the chordate karyotype. Nature, 453(7198), 1064-U3. https://doi.org/10.1038/nature06967
Candiani, S., Holland, N. D., Oliveri, D., Parodi, M., & Pestarino, M. (2008). Expression of the amphioxus Pit-1 gene (AmphiPOU1F1/Pit-1) exclusively in the developing preoral organ, a putative homolog of the vertebrate adenohypophysis. Brain Research Bulletin, 75(2–4), 324–330. https://doi.org/10.1016/j.brainresbull.2007.10.023
Holland, L. Z., & Short, S. (2008). Gene Duplication, Co-Option and Recruitment during the Origin of the Vertebrate Brain from the Invertebrate Chordate Brain. Brain Behavior and Evolution, 72(2), 91–105. https://doi.org/10.1159/000151470
Holland, L. Z., & Holland, N. D. (2007). A revised fate map for amphioxus and the evolution of axial patterning in chordates. Integrative and Comparative Biology, 47(3), 360–372. https://doi.org/10.1093/icb/icm064
Beaster-Jones, L., Schubert, M., & Holland, L. Z. (2007). Cis-regulation of the amphioxus engrailed gene: Insights into evolution of a muscle-specific enhancer. Mechanisms of Development, 124(7–8), 532–542. https://doi.org/10.1016/j.mod.2007.06.002
Kozmik, Z., Holland, N. D., Kreslova, J., Oliveri, D., Schubert, M., Jonasova, K., Holland, L. Z., Pestarino, M., Benes, V., & Candiani, S. (2007). Pax-Six-Eya-Dach network during amphioxus development: Conservation in vitro but context specificity in vivo. Developmental Biology, 306(1), 143–159. https://doi.org/10.1016/j.ydbio.2007.03.009
Holland, L. Z. (2007). Developmental biology - A chordate with a difference. Nature, 447(7141), 153–155. https://doi.org/10.1038/447153a
Rasmussen, S. L. K., Holland, L. Z., Schubert, M., Beaster-Jones, L., & Holland, N. D. (2007). Amphioxus AmphiDelta: Evolution of delta protein structure, segmentation, and neurogenesis. Genesis, 45(3), 113–122. https://doi.org/10.1002/dvg.20278
Yu, J. K., Satou, Y., Holland, N. D., Shin-I, T., Kohara, Y., Satoh, N., Bronner-Fraser, M., & Holland, L. Z. (2007). Axial patterning in cephalochordates and the evolution of the organizer. Nature, 445(7128), 613–617. https://doi.org/10.1038/nature05472
Lin, H. C., Holland, L. Z., & Holland, N. D. (2006). Expression of the AmphiTcf gene in amphioxus: Insights into the evolution of the TCF/LEF gene family during vertebrate evolution. Developmental Dynamics, 235(12), 3396–3403. https://doi.org/10.1002/dvdy.20971